Thinking about starting Zepbound but concerned about cost? Our Medical Director, Dr. Victor Cherfan, DO, has created a helpful guide to explain how you can maximize the value of your prescription with safe and strategic dosing. Keep reading to learn how a few adjustments could save you hundreds—if not thousands—each year.
Last Updated on May 9, 2025 by justin@lifeivtherapy.com
Zepbound Cost-Saving Strategies From Dr. Victor Cherfan, DO
Zepbound (tirzepatide) is a groundbreaking medication for weight loss and metabolic health. However, its cost can be a concern for many patients—especially those paying out-of-pocket. At Life IV Weight Loss, our Medical Director, Dr. Victor Cherfan, DO, has developed a guide to help patients on cash-pay Zepbound vials save money through strategic injection timing and dosing.
Understanding the Difference: Vial vs. Pen
There are two forms of Zepbound on the market:
- Insurance-covered Zepbound®: Comes in a prefilled pen. This is a single-dose device with no ability to modify the dose or stretch the medication.
- Cash-pay Zepbound: Provided in a multi-dose vial. This version allows more flexibility in dosing, which opens the door for cost-saving strategies when used under medical supervision.
The information in this article applies only to patients using the cash-pay vial form of Zepbound, not the insurance-covered pen.
Cash-Pay Pricing for Zepbound Vials
Current pricing when paying out of pocket:
- 2.5 mg: $349
- 5 mg: $499
- 7.5 mg: $499
- 10 mg: $499
To maintain this pricing, patients must refill every 45 days. This ensures ongoing access to Lilly’s preferred cash-pay rate.
Estimated Yearly and Monthly Costs at Different Injection Schedules
By adjusting your injection frequency (with provider supervision), you may reduce your total number of vials needed per year. Here’s how it breaks down:
| Injection Schedule | Total Orders/Yr | Yearly Cost | Monthly Cost | Yearly Savings | Monthly Savings |
|---|---|---|---|---|---|
| Every 7 Days (Standard) | 13.0 | $6,487 | $541 | – | – |
| Every 8 Days | 11.4 | $5,691 | $474 | $796 | $66 |
| Every 9 Days | 10.1 | $5,059 | $421 | $1,428 | $119 |
| Every 10 Days | 9.1 | $4,553 | $379 | $1,934 | $162 |
Why Monthly Matters
While Dr. Cherfan evaluates value over the course of a year, we understand that many patients think month-to-month. That’s why we’ve broken down estimated monthly costs and savings to help you choose what works best for your budget.
Example: Split Dosing With 10 mg Vials
One method involves ordering a 10 mg vial and injecting 5 mg every 5 days. This provides the same average amount as injecting 10 mg every 10 days—while potentially improving medication efficiency and reducing monthly costs.
Always Work With Your Provider
These strategies must be discussed and approved by your prescribing provider. Dosing adjustments may not be appropriate for everyone, and safety always comes first.
What Your Provider Will Consider
- How well you’re responding to the medication
- Your weight loss progress
- Side effects or tolerability
- Medication supply and refill timing
Final Thoughts From Dr. Cherfan
“Affordability is part of accessibility,” says Dr. Cherfan. “Patients deserve guidance that helps them reach their goals without unnecessary financial stress.”
If you’re currently paying cash for your Zepbound vials and want to explore your options, ask your Life IV provider about alternate injection schedules during your next visit.
Disclaimer
This article is for educational purposes only and does not constitute medical advice. Always consult your licensed provider before making any changes to your medication schedule, dosage, or refill timing.